Closest to the valley floor is Mariposa - surrounded by hills on most sides, but otherwise decent. Keep an eye on temps and airport elevation

Closest to the Tioga Pass entrance is Lee Vining, but last time I was there, runway was rather rough and zero services. Mammoth might be the better option and it has full service and a great runway that was recently resurfaced.
Closest major airport to valley floor would be Fresno (FAT), Class C. If you want to avoid Class C, Fresno Downtown Chandler is the other option. FAT does have rental cars, etc.
Warm Regards, Keith (ASEL)